The Effect of Cardiopulmonary Bypass and Hypothermic Circulatory Arrest on Hepatic Histology in Newborn Animals: An Experimental Study
| Autor: | Simon Schneider, Theodor Tirilomis, R. Waldmann-Beushausen, Julia M. Zwiehoff, Friedrich A. Schoendube |
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| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
Biomedical Engineering H&E stain Medicine (miscellaneous) Bioengineering 030204 cardiovascular system & hematology law.invention Biomaterials 03 medical and health sciences 0302 clinical medicine law Edema Biopsy medicine Cardiopulmonary bypass medicine.diagnostic_test business.industry General Medicine Hypothermia 3. Good health Cardiac surgery surgical procedures operative 030228 respiratory system Anesthesia Circulatory system Deep hypothermic circulatory arrest medicine.symptom business circulatory and respiratory physiology |
| Zdroj: | Artificial Organs. 37:E35-E39 |
| ISSN: | 0160-564X |
| Popis: | Still little is known about the effect of cardiac surgery on neonatal hepatic tissue. We examined the effect of cardiopulmonary bypass (CPB) and the effect of deep hypothermic circulatory arrest (DHCA) on neonatal hepatic tissue. Liver biopsies of neonatal piglets were taken after CPB (n = 4), after DHCA (n = 5), and after surgery without CPB (non-CPB; n = 3). Additionally, findings were compared to those of control piglets (n = 9). The liver specimens were fixed, stained with hematoxylin and eosin, and scored regarding inflammatory reaction, hepatocellular edema, and apoptosis. Inflammation score of treated groups was higher than in control; CPB 2.5 ± 0.5, DHCA 1.6 ± 0.4, non-CPB 1.2 ± 0.6, control 0.4 ± 0.3 (P |
| Databáze: | OpenAIRE |
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