A New CoII Complex as a Bulge-Specific Probe for DNA

Autor:	Chien-Chung Cheng, Wen Jwu Wang, Kuo-Shen Chuang, Chi-Fong Luo, Yen-Ning Kuo
Rok vydání:	1999
Předmět:	Stereochemistry Radical Substrate (chemistry) General Chemistry Cleavage (embryo) Catalysis chemistry.chemical_compound chemistry Organic chemistry Reactivity (chemistry) A-DNA Macrocyclic ligand Hydrogen peroxide DNA
Zdroj:	Angewandte Chemie International Edition. 38:1255-1257
ISSN:	1521-3773 1433-7851
DOI:	10.1002/(sici)1521-3773(19990503)38:9<1255::aid-anie1255>3.0.co;2-t
Popis:	Bulge cleavage of two or three bases occurs when a DNA substrate is specifically cleaved oxidatively by [CoII (tfa)2 (happ)] (see picture). Hydrogen peroxide is necessary for the activation of this octahedral complex, which suggests that hydroxyl radicals are the reactive species. The complex has no significant reactivity towards the corresponding sequence in a single-stranded DNA region, and it exhibits only a low affinity towards double-stranded DNA. happ=macrocyclic ligand based on 1,10-phenanthroline, tfa=trifluoroacetate.
Databáze:	OpenAIRE
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