| Autor: |
Robert C. Brasch, Yanjun Fu, Stavros G. Demos, Vincenzo Lucidi, Laure Fournier-Dujardin, Jonathan Palley, Kirill Berejnoi |
| Rok vydání: |
2005 |
| Předmět: |
|
| Zdroj: |
Academic Radiology. 12:S73-S74 |
| ISSN: |
1076-6332 |
| DOI: |
10.1016/j.acra.2005.03.036 |
| Popis: |
about the optical scattering coefficient of the tissue. As with endogenous optical imaging, time domain offers the potential to supersede CW for optical molecular imaging applications. The wealth of information contained in the fluorescence excitation and emission TPSFs permits the depth of the fluorophore to be obtained by even simple sonar-like approaches. Once the fluorophore depth is known, the intensity can be normalized to provide relative fluorophore concentration. In addition to the potential of TD to provide more accurate quantitative estimates of fluorophore depth and concentration than CW, TD enables the measurement of the fluoresence lifetime which CW is unable to provide. This permits the discrimination of fluorophores which may have significantly different fluoresence lifetimes, despite having similar emission spectra which challenges discrimination with intensity-based CW methods. Furthermore, it is known that the fluorescence lifetime can be influenced by the local environment of the fluorophore which provides additional physiological information. Time domain optical molecular imaging is the technological basis for the pre-clinical optical molecular imaging device (SAMITM) developed by ART. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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