Relationship between structure and chromatographic behaviour of secondary alcohols and their derivatives separated by high-resolution gas chromatography with a modified β-cyclodextrin stationary phase

Autor:	Pavol Majek, Pat Sandra, Eva Benická, Ivan Skačáni, Ján Krupčík
Rok vydání:	1994
Předmět:	chemistry.chemical_classification Chromatography Cyclodextrin Chemistry Organic Chemistry High resolution General Medicine Biochemistry Analytical Chemistry Capillary column Stationary phase Molecule Gas chromatography Enantiomer Selectivity
Zdroj:	Journal of Chromatography A. 665:175-184
ISSN:	0021-9673
DOI:	10.1016/0021-9673(94)87046-2
Popis:	Low-boiling secondary alcohols (2-butanol, 2-pentanol and 2- and 3-hexanol) and their methyl, pentyl, acetyl and trifluoroacetyl derivatives were separated by gas chromatography on a fused-sifica capillary column coated with a mixture of OV-1701 and heptakis (6-O- tert .-butyldimethylsilyl-2,3-di-O-acetyl)-β-cyclodextrin (1:1). The retention of these solutes was studied by determining their separation factors (α) and this temperature dependences. The retention of enantiomers was correlated with optical activity and structural data obtained by theoretical calculations. It was demonstrated that the separation of enantiomers on a modified cyclodextrin stationary phase is governed inter alia by total molecule asymmetries.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::9d58aae00c0ea8b085d6bed55fb01658 https://doi.org/10.1016/0021-9673(94)87046-2 Zobrazit plný text záznamu