Identification of drug metabolites in biological matrices by intelligent automated liquid chromatography/ tandem mass spectrometry

Autor:	Xiao Yu, Margaret R. Davis, Donghui Cui, Linda L. Lopez
Rok vydání:	1998
Předmět:	Chromatography Chemistry Organic Chemistry In vitro incubation Mass spectrometry Tandem mass spectrometry High-performance liquid chromatography Analytical Chemistry Liquid chromatography–mass spectrometry Indinavir medicine Spectroscopy Drug metabolism medicine.drug
Zdroj:	Rapid Communications in Mass Spectrometry. 12:1756-1760
ISSN:	1097-0231 0951-4198
Popis:	A rapid and systematic strategy for the identification of drug metabolites in biological matrices based on liquid chromatography - tandem mass spectrometry (LC/MS/MS) techniques was utilized for the identification of drug metabolites of the HIV protease inhibitor Indinavir. This strategy integrates intelligent real-time mass spectrometry with HPLC detection and a predictive strategy for detecting metabolites arising from common biotransformations, to rapidly elucidate structures of drug metabolites. Structures of metabolites generated from in vitro incubation mixtures of Indinavir were characterized from a single chromatographic analysis using the automated LC/MS/MS methodology, thus reducing data acquisition time and improving efficiency. © 1998 John Wiley & Sons, Ltd.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::9d479681095f1fb4f0bf6e975a061b99 https://doi.org/10.1002/(sici)1097-0231(19981130)12:22<1756::aid-rcm381>3.0.co Zobrazit plný text záznamu Plný text