Mechanism of Action of Interleukin-1 in Modulating Gonadotropin Secretion
| Autor: | Flavio Piva, Marina Montagnani Marelli, Donatella Dondi, Patrizia Limonta |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
endocrine system
Pituitary gland medicine.medical_specialty medicine.drug_class Chemistry Interleukin Gonadotropin-releasing hormone Gonadotropin secretion Cellular and Molecular Neuroscience Follicle-stimulating hormone medicine.anatomical_structure Endocrinology Developmental Neuroscience Neurology Internal medicine medicine Gonadotropin Receptor Luteinizing hormone hormones hormone substitutes and hormone antagonists |
| Zdroj: | Neurosignals. 7:55-60 |
| ISSN: | 1424-8638 1424-862X |
| Popis: | To obtain further information on the mode of action of interleukin (IL)-1 in modulating gonadotropin secretion, a series of in vivo and in vitro studies has been performed with the beta-isoform of IL-1. IL-1 beta injected in a lateral ventricle of 3-week-castrated female rats resulted in the expected decrease in serum levels of gonadotropins luteinizing hormone (LH), and follicle-stimulating hormone (FSH), accompanied by a decrease in the number of LH-releasing hormone (LHRH) receptors. These results may indicate that the inhibition of gonadotropin release may result from a decrease in the number of LHRH pituitary receptors either through a direct effect on the pituitary or by modulating the release of LHRH from hypothalamic neurons able to induce a reduction in pituitary LHRH receptors. In vitro studies using the GT1-1 cell line, which specifically produces and secretes LHRH, demonstrated that IL-beta stimulates LHRH release but does not influence intracellular levels of LHRH mRNA. These results seem to indicate that IL-1 beta may act at several levels of the nervous machinery leading to gonadotropin secretion, with a series of effects more complex than previously anticipated. |
| Databáze: | OpenAIRE |
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