THE EVALUATION OF THE EFFECT OF VITAMIN E ON NITROSO-OXIDATIVE PROCESSES IN MUCOUS MEMBRANES OF THE DIGESTIVE ORGANS UNDER THE CONDITIONS OF CYCLOOXYGENASE BLOCKAGE ON THE BACKGROUND OF THE LOW INTENSITY X-RAY IRRADIATION
| Autor: | Kh. M. Ilnytska, L. O. Datsyuk, O. Ya. Sklyarov |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Antioxidant biology medicine.medical_treatment Vitamin E Superoxide dismutase Lipid peroxidation chemistry.chemical_compound Endocrinology Mechanism of action chemistry Indometacin Catalase Myeloperoxidase Internal medicine medicine biology.protein medicine.symptom medicine.drug |
| Zdroj: | Medical and Clinical Chemistry. :13-20 |
| ISSN: | 2414-9934 2410-681X |
| DOI: | 10.11603/mcch.2410-681x.2018.v0.i3.9550 |
| Popis: | Introduction. The simultaneous effect of several ulcerogenic factors, different due to their mechanism of action on the mucous membranes of the digestive organs needs deep elucidation. The studies were focused on the combined effect of the low intensity X-ray irradiation and cyclooxygenase blockage. It is important to evaluate the antioxidant effect of vitamin E under the conditions of simultaneous effect of different pro-inflammatory factors, acting on the nitroso-oxidative processes. The aim of the study – to investigate the effect of vitamin E on nitroso-oxidative processes in the mucous membranes of the digestive organs under the action of the low intensity X-ray irradiation and COX blockage. Research Methods. In the homogenates of the mucous membranes of stomach, small and large intestine in rats (n=64) the activity of NO-synthase, arginase, myeloperoxidase, superoxide dismutase, catalase, TBA-active products,nitrite-anioncontent and sum of nitrites and nitrates were determined. Results and Discussion. It was established that the effect of vitamin E on the background of the low intensity X-ray irradiation resulted in the decrease of iNOSactivity level (р |
| Databáze: | OpenAIRE |
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