Striatal D2 receptors in symptomatic and asymptomatic carriers of dopa-responsive dystonia measured with [11C]-raclopride and positron-emission tomography

Autor:	Edwin Mak, R. de la Fuente-Fernandez, Barry J. Snow, Thomas J. Ruth, T. G. Nygaard, A. J. Stoessl, D. B. Calne, A. B. Naini, Michael Schulzer, Asha Kishore
Rok vydání:	1998
Předmět:	Dystonia Raclopride Levodopa medicine.medical_specialty Dopaminergic medicine.disease Asymptomatic Endocrinology Dopamine receptor D2 Internal medicine Carbidopa medicine Neurology (clinical) medicine.symptom Psychology Asymptomatic carrier medicine.drug
Zdroj:	Neurology. 50:1028-1032
ISSN:	1526-632X 0028-3878
DOI:	10.1212/wnl.50.4.1028
Popis:	We tested the hypothesis that asymptomatic carriers of dopa-responsive dystonia (DRD) have increased dopamine D2 receptors in the striatum that protect them from the clinical manifestations of dopaminergic deficiency. We examined striatal D2-receptor binding in (1) symptomatic subjects (treated and untreated) and (2) asymptomatic gene carriers. Using [11C]-raclopride PET, we found elevated striatal D2-receptor binding in both groups. In one of our drug-naive symptomatic subjects, 7 months of treatment with levodopa/carbidopa did not affect the receptor binding as measured on a second scan. We conclude that increased D2-receptor binding in DRD may be a homeostatic response to the dopaminergic deficit in subjects carrying the DRD gene, but is not the sole factor determining the clinical state of these individuals.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::9d2c8329986315711c1e1ce806036673 https://doi.org/10.1212/wnl.50.4.1028 Zobrazit plný text záznamu