Preparation and characterization of polymeric nanoparticles composed of poly(dl-lactide-co-glycolide) and poly(dl-lactide-co-glycolide)-co-poly(ethylene glycol)-10%-Triblock end-capped with a galactose moiety
| Autor: | Krasimira T. Petrova, Inês N. Peça, M. Margarida Cardoso, M. Teresa Barros |
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| Rok vydání: | 2012 |
| Předmět: |
Polymers and Plastics
General Chemical Engineering technology industry and agriculture Nanoparticle General Chemistry Polymeric nanoparticles Biochemistry chemistry.chemical_compound chemistry X-ray photoelectron spectroscopy Galactose Drug delivery Polymer chemistry Materials Chemistry Environmental Chemistry Moiety Ethylene glycol Conjugate |
| Zdroj: | Reactive and Functional Polymers. 72:729-735 |
| ISSN: | 1381-5148 |
| Popis: | This work aimed at the synthesis of novel type of targetable polymeric conjugates with a sugar moiety (galactose) with potential application for liver-specific drug delivery. Simple and effective synthesis of poly( dl -lactide-co-glycolide)-galactose conjugate and poly( dl -lactide-co-glycolide)-co-poly(ethylene glycol)-10%-Triblock-galactose conjugate by esterification of the end carboxyl groups has been reported. Spherical hydrophilic nanoparticles with elevated galactose content on the surface were prepared from these polymeric conjugates, and their physical properties were determined by DLS, SEM, XPS and DSC. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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