Utility of Fetal Cardiac Axis and Cardiac Position Assessment in Predicting Neonatal Respiratory Morbidity in Fetal Congenital Lung Lesions
| Autor: | Orly Levit, David H. Stitelman, Mert Ozan Bahtiyar, Lea Tuzovic, Joshua A. Copel |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Fetus
medicine.medical_specialty 030219 obstetrics & reproductive medicine Lung Radiological and Ultrasound Technology business.industry Congenital pulmonary airway malformation PULMONARY MALFORMATION Retrospective cohort study medicine.disease Cardiac axis 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Internal medicine Respiratory morbidity medicine Cardiology Gestation Radiology Nuclear Medicine and imaging business |
| Zdroj: | Journal of Ultrasound in Medicine. 38:2361-2372 |
| ISSN: | 0278-4297 |
| Popis: | Objectives To assess the diagnostic performance of the fetal cardiac axis (CA) and/or cardiac position (CP) versus the congenital pulmonary malformation volume ratio (CVR) in predicting any and severe neonatal respiratory morbidity in fetal congenital lung lesions. Methods This work was an 11-year retrospective cohort study. The sensitivity, specificity, positive predictive value, and negative predictive value of CA and/or CP assessment in prediction of respiratory morbidity were calculated before 24 weeks' gestation and between 24 and 32 weeks and compared to CVR cutoffs obtained from the literature. Results Fifty-three patients were included. CA and/or CP abnormalities were present in 45% and 38% of patients before 24 weeks and between 24 and 32 weeks and were significantly more common in left- versus right-sided lesions (60% versus 17%; P = .003). The sensitivity, specificity, positive predictive value, and negative predictive value of an abnormal CA and/or CP for any and severe respiratory morbidity were 0.67, 0.61, 0.33, and 0.86 and 0.8, 0.58, 0.17, and 0.97 before 24 weeks and 0.75, 0.73, 0.45, and 0.91 and 0.8, 0.67, 0.20, and 0.97 between 24 and 32 weeks, respectively. An abnormal CA and/or CP had higher sensitivity for any respiratory morbidity compared to the CVR at 0.5 and 0.8 cutoffs both before 24 weeks and between 24 and 32 weeks (P Conclusions An abnormal CA and/or CP before 24 weeks and between 24 and 32 weeks has higher sensitivity for the detection of any respiratory morbidity at birth compared to the CVR at both 0.5 and 0.8 cutoffs. A normal CA and CP have a high negative predictive value for excluding any respiratory morbidity at birth both before 24 weeks and between 24 and 32 weeks. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text