Molecularly imprinted self-assembled films with specificity to cholesterol
| Autor: | Anna V. El'skaya, T.A. Sergeyeva, Sergey A. Piletsky, E. V. Piletskaya, T L Panasyuk |
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| Rok vydání: | 1999 |
| Předmět: |
Metals and Alloys
Self-assembled monolayer Condensed Matter Physics Electrochemistry Photochemistry Surfaces Coatings and Films Electronic Optical and Magnetic Materials Potassium ferricyanide chemistry.chemical_compound Adsorption Molecular recognition chemistry Electrode Monolayer Materials Chemistry Organic chemistry lipids (amino acids peptides and proteins) Electrical and Electronic Engineering Molecular imprinting Instrumentation |
| Zdroj: | Sensors and Actuators B: Chemical. 60:216-220 |
| ISSN: | 0925-4005 |
| Popis: | Molecularly imprinted hydrophobic monolayers have been fabricated by spontaneous self-assembly of hexadecyl mercaptan in the presence of cholesterol on gold surfaces. The lypophilic layer of long chain hexadecan have been formed around the template molecules adsorbed on gold surface. The extraction of cholesterol has resulted in formation of sites in the layer of hexadecyl mercaptan which could selectively re-bind the template molecules. The imprinting cavities have been used as channels for potassium ferricyanide which was reduced at the electrode surface. It has been shown, that the molecular recognition process running inside of these channels diminished the mass-transport of potassium ferricyanide to the electrode surface and consequently reduced an electrochemical signal. The change of potassium ferricyanide reduction peak has been related to the template concentration. The formation of the cholesterol-specific monolayers, their specificity and stability has been studied and the possibility of its application for sensor development has been discussed. |
| Databáze: | OpenAIRE |
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