Metabolism of morphine and codeine by guinea-pig liver microsomal preparations and by rats

Autor:	Samia W. El-Dabbas, J. David Phillipson, J. W. Gorrod
Rok vydání:	1978
Předmět:	Pharmacology Metabolite Codeine Metabolism Guinea pig chemistry.chemical_compound chemistry Tacrine medicine Morphine Microsome Pharmacology (medical) Incubation medicine.drug
Zdroj:	European Journal of Drug Metabolism and Pharmacokinetics. 3:119-124
ISSN:	2107-0180 0378-7966
DOI:	10.1007/bf03189380
Popis:	Incubation of morphine with guinea-pig liver microsomal preparations resulted in the formation of 0.9% of the major isomer of morphineN-oxide (I) whereas with codeine, 19.5% of the major isomer (HI) and 0.1% of the minor isomer (IV) of codeineN-oxide were formed. Morphine — and codeineN-oxides (major isomers) were isolated in low concentrations from rat urine after administration of the corresponding tertiary alkaloids. When tacrine was given concommitantly, there were no significant increases inN-oxide formation eitherin vitro orin vivo. Codeine was identified as a metabolite of morphine after incubation with guinea-pig liver microsomes and after injection into rats.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::9d1c1dad92c1e829fe55424eaa0515af https://doi.org/10.1007/bf03189380 Zobrazit plný text záznamu Full text from SpringerLink