Study of Surfactant (Benzyldimethylhexadecylammonium Chloride) Effect on Selected Properties of Hydrogels
| Autor: | Jarmila Oremusová, Petra Herdová, Vitková Z |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
General Chemical Engineering
Enthalpy technology industry and agriculture General Chemistry Condensed Matter Physics complex mixtures Chloride Gibbs free energy Chitosan symbols.namesake chemistry.chemical_compound chemistry Pulmonary surfactant Critical micelle concentration Self-healing hydrogels Polymer chemistry symbols medicine Solubility Nuclear chemistry medicine.drug |
| Zdroj: | Tenside Surfactants Detergents. 51:46-53 |
| ISSN: | 2195-8564 0932-3414 |
| DOI: | 10.3139/113.110285 |
| Popis: | This paper aims to provide analysis of the influences of concentration changes of the surfactant – benzyldimethylhexadecylammonium chloride in hydrogels on their liberation, rheological, association and solubility properties. The hydrogels contained constant amounts of the gel-creating basis (polymer chitosan – 2.5 % w/w), the drug (chlorhexidine dihydrochloride – 0.1 % w/w) and the surfactant, which was used as an enhancer (0.005 – 0.05 % w/w). The highest value of the released drug corresponded to the highest surfactant concentration in the hydrogel. Critical micelle concentration and thermodynamic parameters, molar Gibbs energy, enthalpy and entropy of micellization were calculated. A linear increase of the surfactant amounts in hydrogels caused a non-linear increase of the cloud point. The appearance of the surfactant's associates in hydrogels influenced both their liberation and rheological properties. |
| Databáze: | OpenAIRE |
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