C-Fos Digital Expression Analysis in Human PapillomavirusRelated Oral Squamous Cell Carcinoma
| Autor: | Athanasios Niotis, Maria Adamopoulou, Efthymios Kyrodimos, Dimitrios Roukas, Despoina Spyropoulou, Vasileios Ragos, Chara Stavraka, Aristeidis Chrysovergis, Evangelos Tsiambas, Vasileios Papanikolaou, Dimitrios Peschos, Nicholas S Mastronikolis |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
biology
Cell Building and Construction medicine.disease c-Fos Intracellular signal transduction stomatognathic diseases medicine.anatomical_structure Downregulation and upregulation biology.protein Carcinoma medicine Cancer research Immunohistochemistry Electrical and Electronic Engineering Gene Transcription factor |
| Zdroj: | Asian Pacific Journal of Cancer Biology. 6:117-121 |
| ISSN: | 2538-4635 |
| DOI: | 10.31557/apjcb.2021.6.2.117-121 |
| Popis: | Background: Fos Proto-Oncogene (c-Fos) represents a well analyzed gene involved in solid malignancies’ development and progression. The corresponding protein forms heterodimer with c-jun, a strong transcription factor. C-Fos/c-Jun complex influences critically the intracellular signal transduction to the nucleus. Our aim was to detect and evaluate c-Fos protein expression patterns in oral squamous cell carcinomas (OSCC) tissues. Materials and Methods: Fifty (n=50) formalin-fixed, paraffin-embedded primary OSCCs tissue sections were used. Immunohistochemistry and digital image analysis were implemented for identifying and evaluating c-Fos protein expression levels, respectively. Results: C-Fos protein over expression (moderate to high imunostaining intensity values) was observed in 28/50 (56%) tissue cores, whereas low expression rates were detected in the rest of the examined cases (22/50- 44%). C-Fos overall expression was strongly associated with the stage and grade of the examined tumors (p=0.014, p=0.003, respectively) and also with Human papillomavirus (HPV) persistent infection (p=0.004). c-Fos up regulation is frequently observed in OSCCs. Conclusion: C-Fos high expression levels are correlated with an aggressive phenotype (advanced stage/lymph node metastasis) in patients with OSCC, especially in HPV positive cases, especially High Risk subtypes. Due to its elevated oncogenic activity, c-Fos should be a target for novel therapeutic strategies in OSCC combined or not with other oncogenes involving in signaling transduction pathways. |
| Databáze: | OpenAIRE |
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