Supramolecular protection-mediated one-pot synthesis of cationic gold nanoparticles
| Autor: | Myoung-Hwan Park, Ja-Hyoung Ryu, Seongeon Jin, Kibeom Kim, Seongchan Kim, Kwan Hyi Lee, Min-Soo Kim, Hyojin Lee, Huyeon Choi, Chaekyu Kim, Jungmin Lee, Youngdo Jeong, Batakrishna Jana |
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| Rok vydání: | 2020 |
| Předmět: |
Aqueous solution
Chemistry General Chemical Engineering One-pot synthesis Supramolecular chemistry Cationic polymerization 02 engineering and technology 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences Combinatorial chemistry 0104 chemical sciences Electrostatic attraction Colloidal gold Shielding effect Molecule 0210 nano-technology |
| Zdroj: | Journal of Industrial and Engineering Chemistry. 81:303-308 |
| ISSN: | 1226-086X |
| DOI: | 10.1016/j.jiec.2019.09.018 |
| Popis: | Despite the extended use of cationic gold nanoparticles (AuNPs) in biomedical applications, direct one-pot synthesis of AuNPs with tunable size in aqueous media is limited due to the deleterious electrostatic attraction between AuCl4-anions and positively charged ligands. This paper describes the one-pot synthesis of cationic gold nanoparticles with size tunability based on host-guest chemistry. As the host molecule, cucurbit[7]uril inhibits self-aggregation in aqueous solution by threading positively charged guest ligands, which provides a shielding effect on the ligands. Reduction of the mixtures by directly adding NaBH4 generates cationic AuNPs with narrow size distributions. Furthermore, their potential in biomedical applications is demonstrated by siRNA transfection experiments. This approach relying on supramolecular-mediated interactions may provide new insights into organic/inorganic reactions that involve electrostatic disturbance. |
| Databáze: | OpenAIRE |
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