Abstract 059: Deficiency of Either Prebiotic Dietary Fibre or Prebiotic-Responsive Gut Microbiota Result in High Blood Pressure
| Autor: | Charles R. Mackay, Hamdi A. Jama, Kirill Tsyganov, Gavin W. Lambert, D. Donner, Helen Kiriazis, Grant R Drummond, Sarah E. Phillips, Chad Johnson, Francine Z. Marques, Duncan Horlock, Waled A. Shihata, Antony Vinh, April Fiedler, Mark Ziemann, David M. Kaye, Matthew Snelson, Sam El-Osta, Beverly Giam, Xiao-Jun Du |
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| Rok vydání: | 2019 |
| Předmět: |
biology
Chemistry Prebiotic medicine.medical_treatment Lower blood pressure Dietary fibre 030204 cardiovascular system & hematology Gut flora biology.organism_classification 03 medical and health sciences 0302 clinical medicine Blood pressure Immune system Internal Medicine medicine Upper gastrointestinal 030212 general & internal medicine Food science Digestion |
| Zdroj: | Hypertension. 74 |
| ISSN: | 1524-4563 0194-911X |
| Popis: | Background: High fibre intake is associated with lower blood pressure (BP) in epidemiological and clinical studies. Prebiotic fibre resists digestion in the upper gastrointestinal tract and is fermented by gut microbiota in the intestine. The impact of lack of prebiotic dietary fibre in BP remains unknown. Objectives: To determine the consequences of lack of prebiotic dietary fibre to the development of hypertension through changes in the gut microbiome, associated receptors and immune-based mechanisms using a slow pressor angiotensin II (Ang II) model. Methods: C57BL/6 mice were fed a ‘no fibre’ or ‘high fibre’ diets for 3-weeks prior to sham or Ang II minipump implantation (n=4-21/group), and were followed for 4-weeks post-surgery. Gnotobiotic mice received faecal transplant from ‘no fibre’ sham or Ang II mice (n=5-6/group). Cardiac function, BP and gut microbiome (by 16S sequencing) were determined. Results: Ang II mice that received a ‘no fibre’ diet had significantly higher BP than sham (SBP mean±SEM: 143.7±3.5 vs 91.2±1.8, P Conclusions: Lack of prebiotic dietary fibre leads to the development of a hypertensinogenic gut microbiome, hypertension and its complications. SCFA might represent new therapeutic opportunities through modulation of G-coupled protein receptors and Treg cells. |
| Databáze: | OpenAIRE |
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