The in vitro Antimycobacterial investigation of some basic meta-/para-Alkoxyphenylcarbamic Esters Bearing 4-(4-Fluoro/2-methoxyphenyl)piperazin-1-yl fragment

Autor:	Jozef Csöllei, Lubica Sichrovska, Ivan Malík, Jirina Stolarikova, Lukáš Stanzel, Eva Sedlárová
Rok vydání:	2014
Předmět:	Minimum inhibitory concentration biology medicine.drug_class Stereochemistry Chemistry medicine Pharmaceutical Science Pharmacology (medical) Antimycobacterial biology.organism_classification In vitro Mycobacterium
Zdroj:	Dhaka University Journal of Pharmaceutical Sciences. 12:103-107
ISSN:	1816-1839 1816-1820
DOI:	10.3329/dujps.v12i2.17621
Popis:	Following previous systematical research of ortho -/ meta- / para -alkoxyphenylcarbamic acid esters as antimycobacterially active compounds, the set of the derivatives containing meta -/ para -alkoxyphenylcarbamoyloxy and 4-(4-fluorophenyl/2-methoxyphenyl)piperazin-1-yl moieties were tested for their in vitro activity against tuberculous strain of Mycobacterium ( M. ) tuberculosis CNCTC My 331/88 as well as against potential pathogenic strains of M. kansasii CNCTC My 235/80, M. avium CNCTC My 330/88 and M. kansasii 6 509/96, respectively, by applying the micromethod for the determination of the minimum inhibitory concentration ( MIC ). It is concludut that the molucules posscssed selatively promising activity against M. Tuberculasis and M. Kansas!!. Dhaka Univ. J. Pharm. Sci. 12(2): 103-107, 2013 (December) DOI: http://dx.doi.org/10.3329/dujps.v12i2.17621
Databáze:	OpenAIRE
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