Microemulsion for Intradermal Delivery Of Cetyl Alcohol and Octyl Dimethyl PABA

Autor:	R. C. Pohland, T. K. Byrd, E. E. Linn
Rok vydání:	1990
Předmět:	Pharmacology Macroemulsion Chromatography Franz diffusion cell Chemistry Cetyl alcohol Organic Chemistry Pharmaceutical Science Absorption (skin) chemistry.chemical_compound Lotion Drug Discovery Mouse skin OCTYL DIMETHYL PABA Microemulsion
Zdroj:	Drug Development and Industrial Pharmacy. 16:899-920
ISSN:	1520-5762 0363-9045
DOI:	10.3109/03639049009114917
Popis:	A water-in-oil microemulsion was prepared to deliver cetyl alchohol [I] octyl dimethyl PABA or Padimate-O [II] in vitro using human and hairless mouse skin. A standard Franz diffusion cell and a microsectiong cryostat microtome were used to quantify the rate and the depth of penetration and the results were compared in the percent does penetrated for this microemulsion and two macroemulsion formulations, namely a cream and a lotion. It appeared that the microemulsion had the ability to deliver [I] into the skin 2-6 times faster and at least twice as much as that with the other two formulations. Furthermore, the absorption of [I] from the cream or lotion product could bel enhanced by as much as 50-250% if the skin had been pretreated with microemulsion prior to product application. The advantage of using a microemulison to acheieve deeper and faster penetratin of the permeating compunds was clearly demonstreated in this study.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::9cffc7cece5d0cdcfb4adabdba671b03 https://doi.org/10.3109/03639049009114917 Zobrazit plný text záznamu