Inflammation-induced interstitial migration of effector CD4+ T cells is dependent on integrin αV
| Autor: | Angela Hughson, Mridu Acharya, Adam Lacy-Hulbert, Deborah J. Fowell, David J. Topham, Alison Gaylo, Michael G. Overstreet, Alexander F. Rosenberg, Young-Min Hyun, Hideo Yagita, Martin Meier-Schellersheim, Minsoo Kim, Alison C. Billroth-MacLurg, Bastian R. Angermann, Kris Lambert |
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| Rok vydání: | 2013 |
| Předmět: |
0303 health sciences
Pathology medicine.medical_specialty biology Effector Lymphocyte Immunology Integrin Motility Inflammation 3. Good health Cell biology Extracellular matrix Fibronectin 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Integrin alphaV biology.protein medicine Immunology and Allergy medicine.symptom 030304 developmental biology 030215 immunology |
| Zdroj: | Nature Immunology. 14:949-958 |
| ISSN: | 1529-2916 1529-2908 |
| DOI: | 10.1038/ni.2682 |
| Popis: | Leukocytes must traverse inflamed tissues to effectively control local infection. Although motility in dense tissues seems to be integrin independent and based on actomyosin-mediated protrusion and contraction, during inflammation, changes to the extracellular matrix (ECM) may necessitate distinct motility requirements. Indeed, we found that the interstitial motility of T cells was critically dependent on Arg-Gly-Asp (RGD)-binding integrins in the inflamed dermis. Inflammation-induced deposition of fibronectin was functionally linked to higher expression of integrin αV on effector CD4⁺ T cells. By intravital multiphoton imaging, we found that the motility of CD4⁺ T cells was dependent on αV expression. Selective blockade or knockdown of αV arrested T helper type 1 (TH1) cells in the inflamed tissue and attenuated local effector function. Our data demonstrate context-dependent specificity of lymphocyte movement in inflamed tissues that is essential for protective immunity. |
| Databáze: | OpenAIRE |
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