Synthesis of Some New Substituted Thieno[2,3-d]pyrimidine Derivatives as Antimicrobial Agents

Autor:	A. E. Amr, Hanaa M. Hosni, Mohamed F. El-Shehry, D. H. Elnaggar, Ahmed A. Fayed, Alhussein A. Ibrahim
Rok vydání:	2019
Předmět:	Antifungal Pyrimidine 010405 organic chemistry Chemistry medicine.drug_class Carboxamide General Chemistry 010402 general chemistry Reference drug Antimicrobial 01 natural sciences Combinatorial chemistry 0104 chemical sciences chemistry.chemical_compound medicine Antibacterial activity
Zdroj:	Russian Journal of General Chemistry. 89:1528-1534
ISSN:	1608-3350 1070-3632
DOI:	10.1134/s1070363219070247
Popis:	A series of thieno-pyrimidine derivatives are synthesized from 5′-amino-2,3′-bithiophene-4′-carboxylate via the corresponding intermediate N-benzoylated carboxamide derivatives. The target compounds are tested for antibacterial and antifungal activity. Some of the synthesized compounds demonstrate potent antibacterial activity with LD50 comparable with the reference drug indomethacin.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::9cf9d07cdc55bd2d3fe2a044561a7b5b https://doi.org/10.1134/s1070363219070247 Zobrazit plný text záznamu Plný text ve formátu PDF