Plasma Oligomeric Alpha-Synuclein Is Associated With Glucocerebrosidase Activity in Gaucher Disease
| Autor: | E. P. Nuzhnyi, A. F. Yakimovskii, S. Pchelina, A. K. Emel’yanov, Tatyana Boukina, T.S. Usenko, Ekaterina Zakharova |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Alpha-synuclein
medicine.medical_specialty Pathology Parkinson's disease Disease medicine.disease nervous system diseases Glucocerebrosidase activity chemistry.chemical_compound Endocrinology Neurology chemistry Internal medicine Lysosomal storage disease medicine Biological fluids In patient Neurology (clinical) Glucocerebrosidase |
| Zdroj: | Movement Disorders. 30:989-991 |
| ISSN: | 0885-3185 |
| DOI: | 10.1002/mds.26200 |
| Popis: | Background The link between Parkinson's disease (PD) and Gaucher disease (GD), the most common lysosomal storage disease associated with loss of glucocerebrosidase (GBA) activity, can be explained by abnormal accumulation of oligomeric alpha-synuclein (α-Syn) species resulting from mutations in the GBA gene. However, in GD, the relationship between GBA activity and α-Syn accumulation in biological fluids has not been investigated. Methods We analyzed plasma oligomeric α-Syn levels, leucocyte GBA activity, and plasma chitotriosidase activity in 21 patients with GD. Results Negative correlation between plasma oligomeric α-Syn levels, and leucocyte GBA activity was observed in patients with GD (R2 = 0.487; P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text