Possible anti-Parkinson properties of N-(α-linolenoyl) tyrosine
| Autor: | Shlomo Yehuda |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Pharmacology
chemistry.chemical_classification medicine.medical_specialty Parkinson's disease Clinical Biochemistry Fatty acid Striatum Biology Toxicology medicine.disease Biochemistry Central nervous system disease Behavioral Neuroscience Endocrinology chemistry Dopamine Internal medicine medicine Peptide bond Tyrosine Mode of action Biological Psychiatry medicine.drug |
| Zdroj: | Pharmacology Biochemistry and Behavior. 72:7-11 |
| ISSN: | 0091-3057 |
| Popis: | Tyrosine is unable to cross the blood–brain barrier and is therefore unable to improve the status of brain dopamine (DA) and to provide relief for patients with Parkinson's disease (PD) or other DA-insufficient disorders. We report the creation of an amide bond molecule [ N -(α-linolenoyl)tyrosine (NLT)] that combines tyrosine with a fatty acid mixture. NLT significantly improves the rotational behavior of rats [following unilateral striatal lesions (as a model for Parkinson's)] and overcomes the exaggerated eye-blinking induced by a potent DA-depleting agent (as a model for essential blepharospasm). These results are supported by the finding that NLT's mode of action, in striatum, is the same as the mode of action of d -amphetamine. They both induce an increase in the DA level, DA turnover and release. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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