Prenatal choline supplementation mitigates behavioral alterations associated with prenatal alcohol exposure in rats
| Autor: | Nirelia M. Idrus, Bradley R. Monk, Jennifer D. Thomas, Hector D. Dominguez |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
chemistry.chemical_classification
Embryology medicine.medical_specialty Pregnancy Ethanol business.industry Fetal alcohol syndrome Alcohol General Medicine medicine.disease chemistry.chemical_compound Endocrinology chemistry Internal medicine Pediatrics Perinatology and Child Health medicine Choline Choline supplementation Adverse effect business Essential nutrient Developmental Biology |
| Zdroj: | Birth Defects Research Part A: Clinical and Molecular Teratology. 88:827-837 |
| ISSN: | 1542-0752 |
| DOI: | 10.1002/bdra.20713 |
| Popis: | BACKGROUND Prenatal alcohol exposure can alter physical and behavioral development, leading to a range of fetal alcohol spectrum disorders (FASD). Despite warning labels, pregnant women continue to drink alcohol, creating a need to identify effective interventions to reduce the severity of alcohol’s teratogenic effects. Choline is an essential nutrient that influences brain and behavioral development. Recent studies indicate that choline supplementation can reduce the teratogenic effects of developmental alcohol exposure. The present study examined whether choline supplementation during prenatal ethanol treatment could mitigate the adverse effects of ethanol on behavioral development. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text