| Autor: |
Irfanur Rashid, Shabnam B. Basher, Lutfur Rahman, Rajib Shil, Herman Yeger, Tahmina Banu, Shammy Bithy, Syed S. Islam, Ali Asgar Chowdhury, Walid A. Farhat, Jannatul Aklima, Junayed Nayeem, Abul Hasan, Bedri Karakas, Rashed R Parag, S. S. Alam, Ayesha Siddiqua, Mizanur Rahman, Afsana Shirin, Zillur Rahman, Afrina Chowdhury, Sonam Akther, Chandsultana Jerin, Afrin Sultana, Reaz Mahmud, Abu Shadat Mohammod Noman, Ikram Hossain |
| Rok vydání: |
2018 |
| Předmět: |
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| Zdroj: |
SSRN Electronic Journal. |
| ISSN: |
1556-5068 |
| Popis: |
Importance: Head and neck squamous cell carcinoma (HNSCC) still poses therapeutic challenges due to local recurrence and metastasis. Objective: Explore a reliable biomarker to stratify patients who benefit from adjuvant chemotherapy in HNSCC patients. Design: We analyzed a cohort of HNSCC patients to identify potential candidate biomarker and analyzed overall survival (OS) and disease-free survival (DFS) of these patients who benefit from adjuvant chemotherapy. Results: : Sonic hedgehog (Shh), a secreted signaling molecule identified as a potential candidate biomarker in our analysis. A group of HNSCC patients (106/183) were negative to Shh. In the discovery dataset, the OS (HR 3·231, CI 1·23-8·53, p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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