Proton nuclear magnetic resonance studies of plasma to determine metabolic status of patients with adult respiratory distress syndrome

Autor:	Shu-Mai Chen, Cheng-Deng Kuo, Jia-Horng Wang, B. N. Chiang, Wen Guey Wu
Rok vydání:	1989
Předmět:	ARDS medicine.medical_specialty Lung Respiratory distress Chemistry Biochemistry (medical) Clinical Biochemistry Respiratory disease Metabolic disorder Phenylalanine Metabolism medicine.disease Pulmonary edema medicine.anatomical_structure Endocrinology Internal medicine medicine
Zdroj:	Clinical Chemistry. 35:667-670
ISSN:	1530-8561 0009-9147
DOI:	10.1093/clinchem/35.4.667
Popis:	Adult respiratory distress syndrome (ARDS) is a non-cardiogenic pulmonary edema of various etiologies. Here we report the first application of proton nuclear magnetic resonance (NMR) for the detection of abnormal metabolites in plasma from patients with ARDS. By comparing plasma obtained from the systemic artery with that obtained from the pulmonary artery, we could study the metabolic status of the lung in patients with ARDS. Although their concentrations may vary, the peaks for acetate, acetoacetate, beta-hydroxybutyrate, phenylalanine, and other unidentified compounds in water-suppressed NMR of these patients' plasma were higher than in the normal controls. The proton NMR resonance at a chemical shift of about 7.4 ppm (relative to sodium tetradeutero-3-trimethyl-silylpropionate), presumably caused by phenylalanine and its related metabolites produced by a disordered amino acid metabolism, is detected in greater than 65% of the samples from ARDS patients. We discuss the detection of abnormal metabolites in terms of possible deranged metabolism of carbohydrates, lipids, or amino acids in this syndrome.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::9cd58343c0c82ece7bed781abf9cff39 https://doi.org/10.1093/clinchem/35.4.667 Zobrazit plný text záznamu