HLA Antigens in Essential Hypertension

Autor:	Paul L. Andersen, Bent Ø. Kristensen, L. U. Lamm, Flemming Kissmeyer-Nielsen
Rok vydání:	2008
Předmět:	Immunology Autoantibody General Medicine Disposition Human leukocyte antigen Biology medicine.disease Essential hypertension Biochemistry Antigen Diabetes mellitus Genetics medicine biology.protein Immunology and Allergy Family history Antibody
Zdroj:	Tissue Antigens. 10:70-74
ISSN:	1399-0039 0001-2815
Popis:	HLA-typing was performed in 149 patients with essential hypertension, 86 males and 63 females. In 66 patients with significantly elevated serum levels of immunoglobulins, HLA-B27 was increased to 18%, from 8% in the controls (P less than 0.007). This was not significant when correcting the P-value for the number of antigens analyzed, but confirms reports of an association of this antigen with serum levels of immunoglobulins. HLA-Bw15 was found to be increased two-fold in patients with a family history of hypertension (P corrected less than 0.05) and in patients with autoantibodies (not significant). This is discussed in relation to the increase of Bw15 in juvenile diabetes and in Systemic Lupus Erythematosus, diseases in which vascular damage also occurs.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::9cd2c8b0b3ab9ec05688ca2fbe6c8b01 https://doi.org/10.1111/j.1399-0039.1977.tb01121.x Zobrazit plný text záznamu Plný text