| Autor: |
Hardik Soni, Swati Bhatt, Siddhi Upadhyay, Umesh Upadhyay, Prateek Patel |
| Rok vydání: |
2013 |
| Předmět: |
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| Zdroj: |
International Research Journal of Pharmacy. 4:213-215 |
| ISSN: |
2230-8407 |
| DOI: |
10.7897/2230-8407.04544 |
| Popis: |
Objective: To evaluate the Acute toxicity study and Anti - asthmatic activity of Zeal Herbal Granules. Materials & Methods: In the present study, acute toxicity study was carried o ut as per OECD guideline 423. Anti - asthmatic activity of Zeal Herbal Granules was investigated against c ompound 48/80 - induced mast cell degranulation. Percentage mast cell degranulation was calculated at different concentration level i.e.1, 10, 100 and 100 0μg/mL. Results: Zeal Herbal Granules showed significant protection of rat mesenteric mast cells from disruption caused by compound 48/80. Significant dose depende nt effect was observed in percentage mast cell degranulation at different dose level of Zeal Herbal Granules in comparison to negative control. 26.83% mast cell degranulation was observed at 100μg/mL dose level of Zeal Herbal Granules. Conclusion: The present study revealed that Zeal Herbal Granules has significant anti - asthmatic activity against compound 48/80 - induced mast cell degranulation comparable to that produced by Ketotifen fumarate. There was no lethal and toxic reactions found among the tested animals. Zeal Herbal Granules can be a safe and effective drug for patient with asthmatic compl aints. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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