Relationships between Myocardial Damage Biomarkers with Infarct Size and Ejection Fraction Impairment Assessed by Cardiac Magnetic Resonance
| Autor: | Rodolfo Prieto-Riveros, Lucia Del Valle-Batalla, Kjersti Nes, Rubén Aguayo, Ramón Rodrigo, Jaime González, Raul Castillo-Astorga, Juan Carlos Prieto, Cristóbal Ramos |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Ejection fraction biology business.industry medicine.medical_treatment Gold standard (test) Venous blood medicine.disease Peripheral Internal medicine Angioplasty cardiovascular system medicine Cardiology biology.protein Creatine kinase cardiovascular diseases Myocardial infarction business Cardiac magnetic resonance |
| DOI: | 10.9734/bpi/nfmmr/v8/3917f |
| Popis: | Background: Acute myocardial infarction (AMI) is the leading cause of morbidity and mortality worldwide. The final infarct size (FIS) and left ventricular ejection fraction (LVEF) are the greatest predictors of post-AMI mortality, with cardiac magnetic resonance (CMR) being the gold standard method for their measurement. Myocardial damage biomarkers, such as creatine kinase (CK) and myocardial creatine kinase (CKMB) are currently used to diagnose AMI and estimate the myocardial damage extent. It would be plausible to use them as predictors of FIS and LVEF; however, current evidence is not available up to date. Objective: To determine the potential power of plasma CK and CKMB levels as predictors of FIS and LVEF impairment, respectively, on the basis of their correlation in patients undergoing primary coronary angioplasty (PCA) following ST-elevation acute myocardial infarction (STEMI). Methodology: A retrospective analysis of PREVEC Trial (ISRCTN registry: 56034553), a multicentric, randomized, double-blind clinical study was performed. Sixty-seven patients with STEMI scheduled for PCA were enrolled. The CMR was performed 7-15 days after the event. Three radiologists blinded to clinical information measured FIS and LVEF. Total CK and CKMB were measured in peripheral venous blood at 6-8 hours after PCA. Correlation coefficient were obtained, and the tests were considered significant with a p value |
| Databáze: | OpenAIRE |
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