Untersuchung von Bestandteilen eines pflanzlichen Antidiarrhoikums auf spasmolytische Effekte

Autor:	Eugen J. Verspohl, Andreas Biller, Katrin Bauer
Rok vydání:	2008
Předmět:	Pharmacology Papaverine Chamomile extract Chromatography food.ingredient Pectin Chemistry food and beverages Ileum Apple pectin Fluid extract Concentration dependent medicine.anatomical_structure food Complementary and alternative medicine Biochemistry medicine medicine.drug
Zdroj:	Zeitschrift für Phytotherapie. 29:169-172
ISSN:	1438-9584 0722-348X
DOI:	10.1055/s-0028-1086047
Popis:	SPASMOLYTIC ACTIVITY OF THE CONSTITUENTS OF A HERBAL ANTIDIARRHEIC DRUGThe constituents of Diarrhoesan ® , apple pectin and chamomile flower fluid extract were tested alone and in combination for additive or antagonistic effects. As test system, the inhibition of the spasmodic effect of K + in isolated rat ileum was chosen. K+ induced a contraction in a concentration dependent manner between 3.2 and 32 mM KCl. The results obtained with the reference group (4 × 10 -5 M papaverine) confirm the sensitivity of the test system. Pectin (2.5 mg/ml) alone had no effect. The chamomile fluid extract (2.0 mg/ml) proved to be spasmolytic. In combination with pectin the effect of the chamomile extract (same concentrations used) was unchanged, except for the irrelevant high K + concentration of 32 mM. These findings show that the addition of pectin does not influence the spasmolytic effect of chamomile fluid extract.
Databáze:	OpenAIRE
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