AB0098 ASSOCIATED FACTORS IN ONE-YEAR MORTALITY IN PATIENTS WITH SMALL VESSEL SYSTEMIC VASCULITIS
| Autor: | D. Miranda, Z. Castro, M. J. R. Arriga Torres, Miguel A. Saavedra, E. M. Escudero Tepale |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
education.field_of_study business.industry Mortality rate Immunology Population Retrospective cohort study medicine.disease Gastroenterology General Biochemistry Genetics and Molecular Biology Rheumatology Internal medicine medicine Immunology and Allergy Hypoalbuminemia Microscopic polyangiitis business Granulomatosis with polyangiitis Vasculitis education Systemic vasculitis |
| Zdroj: | Annals of the Rheumatic Diseases. 80:1078.2-1078 |
| ISSN: | 1468-2060 0003-4967 |
| DOI: | 10.1136/annrheumdis-2021-eular.4207 |
| Popis: | Background:The highest mortality rates in patients with small vessel systemic vasculitis occur within the first year after the diagnosis, however associated factors have been scarcely studied in our population.Objectives:To identify mortality associated factors at the time of diagnosis in patients with small vessel systemic vasculitis.Methods:Retrospective cohort (2009-2020) involving 81 patients diagnosed with systemic small vessel vasculitis. Demographic, clinical and biochemical parameters were studied as potential factors associated with one-year mortality.Results:Of the total of patients (n=81), 36 (44.4%) had generalized granulomatosis with polyangiitis, 32 (39.5%) had localized granulomatosis with polyangiitis and 5 (6.2%) had early systemic granulomatosis with polyangiitis, 7 (8.6%) had microscopic polyangiitis and 1 (1.25%) had eosinophilic granulomatosis with polyangiitis. Twenty-two deaths (27%) were observed, 14 of them (63.6%) happened within the first year of diagnosis. The leading cause of death was infection (64%). Patients who died within the first year of diagnosis had a higher frequency of hypoalbuminemia (p=0.05) and also presented hemoglobin lower than 10.8 g/dL (p=0.035) in comparison with those who died after the first year of diagnosis. Remission induction treatment did not differ between both groups.Conclusion:Our study suggests that hypoalbuminemia and anemia are factors associated with a higher mortality within the first year after the diagnosis in patients with systemic small vessel vasculitis which contrast with previously reported data. The study design and the reduced number of patients are two major limitations of the study.References:[1]Flossmann O, Berden A, Groot K, et al. Long-term patient survival in ANCA-associated vasculitis. Ann Rheum Dis. 2011;70:488-94.Disclosure of Interests:None declared |
| Databáze: | OpenAIRE |
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