Pohlianins A, B and C, cyclic peptides from the laxes of Jatropha pohliana ssp. molissima
| Autor: | Bernard Bodo, Catherine Auvin-Guette, Jean-Louis Pousset, Haroudo Satiro Xavier, Alain Blond, Carine Baraguey |
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| Rok vydání: | 1999 |
| Předmět: |
chemistry.chemical_classification
Chromatography biology Organic Chemistry Euphorbiaceae Jatropha biology.organism_classification Mass spectrometry Biochemistry High-performance liquid chromatography Cyclic peptide Homonuclear molecule chemistry Heteronuclear molecule Drug Discovery Chemical decomposition |
| Zdroj: | Tetrahedron. 55:11495-11510 |
| ISSN: | 0040-4020 |
| DOI: | 10.1016/s0040-4020(99)00660-2 |
| Popis: | From the EtOAc extract of the latex of Jatropha pohliana (Euphorbiaceae), two cyclic heptapeptides, pohlianins A (1) and B (2) and one cyclic octapeptide, pohlianin C (3) were isolated by a multi-step chromatography procedure, including HPLC. Their structure were elucidated by chemical degradation, mass spectrometry, homonuclear and heteronuclear NMR experiments. Conformational analysis of these peptides was made by using NMR experiments and distance geometry calculations. Their antimalarial activities were examined. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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