Effect of prolonged low-frequency stimulation on acetylcholine sensitivity of the postsynaptic membrane during blocking of neuromuscular transmission

Autor:	G. I. Poletaev, E. E. Nikol'skii
Rok vydání:	1976
Předmět:	Sartorius muscle End-plate potential Physiology Chemistry General Neuroscience Neuromuscular transmission Inhibitory postsynaptic potential Antidromic Postsynaptic potential medicine Biophysics Excitatory postsynaptic potential Neuroscience Acetylcholine medicine.drug
Zdroj:	Neurophysiology. 7:428-433
ISSN:	1573-9007 0090-2977
DOI:	10.1007/bf01067814
Popis:	Sensitivity of the postsynaptic chemoreceptive membrane of the frog sartorius muscle fiber to acetylcholine was studied during the development of a block to neuromuscular transmission in the course of prolonged indirect low-frequency stimulation. Calculation of the mean amplitude of miniature end-plate potentials, measurement of the input resistance of the electrogenic membrane of the muscle fiber, and application of acetylcholine to the postsynaptic membrane showed that sensitivity of the postsynaptic membrane to mediator is unchanged at the time of onset of the neuromuscular block. A decrease in amplitude of the end-plate potentials during development of fatigue is due to a reduction in their quantum composition, consequent upon negative antidromic influences from the muscle on motor nerve endings, with the participation of chemical agents formed in the muscle during the activity of its contractile system.
Databáze:	OpenAIRE
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