| Autor: |
Bernardo Rudy, Bernard Attali, Lily Yeh Jan, Xiaoliang Wang, M. Hunter Giese, James S. Trimmer, David McKinnon, George A. Gutman, Jeanne M. Nerbonne, Michel Lazdunski, Stephan Grissmer, Walter Stühmer, K. George Chandy, Gail A. Robertson, Luis A. Pardo, Michael C. Sanguinetti |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
IUPHAR/BPS Guide to Pharmacology CITE. 2021 |
| ISSN: |
2633-1020 |
| DOI: |
10.2218/gtopdb/f81/2021.3 |
| Popis: |
The 6TM family of K channels comprises the voltage-gated KV subfamilies, the EAG subfamily (which includes hERG channels), the Ca2+-activated Slo subfamily (actually with 7TM, termed BK) and the Ca2+-activated SK subfamily. These channels possess a pore-forming α subunit that comprise tetramers of identical subunits (homomeric) or of different subunits (heteromeric). Heteromeric channels can only be formed within subfamilies (e.g. Kv1.1 with Kv1.2; Kv7.2 with Kv7.3). The pharmacology largely reflects the subunit composition of the functional channel. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
