Practical synthesis of 1,3-diaryl-5-alkylpyrazoles by a highly regioselective N-arylation of 3,5-disubstituted pyrazoles with 4-fluoronitrobenzene

Autor:	Kirrane Thomas M, Xiao-Jun Wang, John R. Proudfoot, Jonathan Tan, Grozinger Karl G, Raj Betageri
Rok vydání:	2000
Předmět:	Chemistry Yield (chemistry) Organic Chemistry Drug Discovery Regioselectivity Organic chemistry Biochemistry Medicinal chemistry
Zdroj:	Tetrahedron Letters. 41:5321-5324
ISSN:	0040-4039
DOI:	10.1016/s0040-4039(00)00849-2
Popis:	3-Aryl-5-alkylpyrazoles undergo a highly regioselective arylation on N-1 atom with 4-fluoronitrobenzene in the presence of base to yield the corresponding 1-(4-nitrophenyl)pyrazoles.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::9c95d138711d90fd91f3fc4463a7b277 https://doi.org/10.1016/s0040-4039(00)00849-2 Zobrazit plný text záznamu Full Text from ScienceDirect