Effects of the tumor promoter 12-0-tetradecanoyl-phorbol-13-acetate on the wasp,Bracon hebetor
| Autor: | D. S. Grosch, R. G. Best |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
medicine.medical_specialty
Necrosis Physiology Bracon hebetor Intercellular transport General Medicine Biology biology.organism_classification Fecundity Biochemistry Ovariole chemistry.chemical_compound Endocrinology chemistry Insect Science Internal medicine Botany medicine Phorbol Biological half-life medicine.symptom Receptor |
| Zdroj: | Archives of Insect Biochemistry and Physiology. 3:529-538 |
| ISSN: | 1520-6327 0739-4462 |
| DOI: | 10.1002/arch.940030604 |
| Popis: | A single oral dose of the tumor promoter, 12-0-tetradecanoyl-phorbol-13-acetate (TPA), caused a rapid necrosis of the ovarioles, aberrations in the developmental sequence of oocytes, and a concomitant dose-dependent decline in egg production in the wasp, Bracon hebetor. TPA and its metabolities were found to have a biological half life of 26.7 h, with a peak concentration in the ovarioles in 3 h. Damage to ovariole tissue was persistent despite the relatively short half life. Other tissues in the wasp were largely unaffected, although TPA induced lethargy that persisted until death. There was no shortening of life span. Inhibition of intercellular transport and metabolic cooperation may account for decreased fecundity and fertility, but interaction with a phorbol ester receptor is more likely to account for developmental changes and central nervous system poisoning. |
| Databáze: | OpenAIRE |
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