Carbamazepine-Induced Toxic Effects and HLA-B*1502 Screening in Taiwan
| Autor: | Yung-Chu Hsu, Hsiang-Yu Yu, Hung-Ting Liao, Hui-Ping Chuang, Chien-Hsiun Chen, Yu-Hsiang Su, Jer-Yuarn Wu, Shu-Yi Lin, Jing-Jane Tsai, Sheng-Feng Sung, Long-Sun Ro, Cheng-Hsien Lu, Chung-Ta Lu, Chih-Ta Tai, Yu-Hsuan Lin, Shey-Lin Wu, Yuan-Tsong Chen, Li-Chen Huang, Chen-Yang Shen, Peiyuan F. Hsieh, Ying Ju Chen, Luke I Chen, Sheng-Hsing Lan, Wen-Hung Chung, Juei-Jueng Lin, Pei-Joung Tsai, Chin-Song Lu, Cheung-Ter Ong, Chun-Che Chu, Shuen-Iu Hung, Pei Chen, Chi-Feng Chang, Chih-Chao Yang |
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| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
medicine.diagnostic_test business.industry Incidence (epidemiology) medicine.medical_treatment General Medicine Carbamazepine Southeast asian medicine.disease Toxic epidermal necrolysis Anticonvulsant Internal medicine Immunology medicine Young adult business Pharmacogenetics medicine.drug Genetic testing |
| Zdroj: | New England Journal of Medicine. 364:1126-1133 |
| ISSN: | 1533-4406 0028-4793 |
| Popis: | Background Carbamazepine, an anticonvulsant and a mood-stabilizing drug, is the main cause of the Stevens–Johnson syndrome (SJS) and its related disease, toxic epidermal necrolysis (TEN), in Southeast Asian countries. Carbamazepine-induced SJS–TEN is strongly associated with the HLA-B*1502 allele. We sought to prevent carbamazepine-induced SJS–TEN by using HLA-B*1502 screening to prospectively identify subjects at genetic risk for the condition. Methods From 23 hospitals in Taiwan, we recruited 4877 candidate subjects who had not taken carbamazepine. We genotyped DNA purified from the subjects' peripheral blood to determine whether they carried the HLA-B*1502 allele. Those testing positive for HLA-B*1502 (7.7% of the total) were advised not to take carbamazepine and were given an alternative medication or advised to continue taking their prestudy medication; those testing negative (92.3%) were advised to take carbamazepine. We interviewed the subjects by telephone once a week for 2 months to monitor them ... |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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