Synthesis and biological evaluation of novel phane-structured diazacrowns containing γ-piperidone and pyridine rings

Autor:	Van Thi Thanh Tran, Van T. Tran, Victor N. Khrustalev, Anh T. Le, Hieu H. Truong, Linh M. Nguyen, Dat Tien Nguyen, Sang T. Truong, Son T. Mai
Rok vydání:	2020
Předmět:	010405 organic chemistry Stereochemistry General Chemistry 010402 general chemistry Antimicrobial 01 natural sciences In vitro 0104 chemical sciences chemistry.chemical_compound chemistry Pyridine Vero cell Moiety Ammonium acetate Human cancer Biological evaluation
Zdroj:	Mendeleev Communications. 30:753-755
ISSN:	0959-9436
Popis:	Six novel phane-structured diazacrowns containing γ-piperidone and pyridine rings were synthesized from podand 2-+,6-bis(2-formylphenoxymethyl)pyridine, with the γ-piperidone moiety having been constructed in the course of its domino condensation with simple ketones and ammonium acetate. The compounds were tested in vitro for antimicrobial and cytotoxic activity against four human cancer cell lines (Hep-G2, RD, MCF-7, Lu-1) and the Vero cell line. X-Ray structure study of one representative compound revealed its rac-1RS,23SR,24RS,26SR configuration.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::9c88f42363b6f416243f80366060bddf https://doi.org/10.1016/j.mencom.2020.11.021 Zobrazit plný text záznamu Full Text from ScienceDirect