Challenge with fumonisins B1 and B2 changes IGF-1 and GHR mRNA expression in liver of Nile tilapia fingerlings
| Autor: | D.L. Hedler, S.C. Claudino-Silva, Bruno Lala, C.S. Nascimento, Eliane Gasparino, Christiano Rodrigues Schamber, Natália Holtz Alves Pedroso Mora, V.V. Pereira |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Fumonisin B2 Fumonisin B1 biology 030106 microbiology Public Health Environmental and Occupational Health Growth hormone receptor Toxicology biology.organism_classification Feed conversion ratio 03 medical and health sciences chemistry.chemical_compound Oreochromis Nile tilapia 030104 developmental biology Animal science chemistry Fumonisin medicine medicine.symptom Weight gain Food Science |
| Zdroj: | World Mycotoxin Journal. 11:237-245 |
| ISSN: | 1875-0796 1875-0710 |
| Popis: | Although fumonisins are identified as responsible for alterations in weight gain, little information is available on their effects on expression of growth-related genes, especially for Nile tilapia (Oreochromis niloticus) fingerlings. In this study, Nile tilapia fingerlings were treated with increasing levels of fumonisin B1 (FB1) and fumonisin B2 (FB2) (diets of 0, 20, 40, and 60 mg/kg) to evaluate their effects on weight gain (WG), feed intake (FI), feed efficiency (FE), growth hormone receptor (GHR) and insulin growth factor 1 (IGF-1) mRNA expression in liver of this fish. All variables were evaluated at 15 and 30 days of treatment. Diet containing 0 mg fumonisin/kg was used as control treatment. Treatment with 20, 40, and 60 mg fumonisin/kg of diet significantly reduced WG (P1 + FB2) affect the growth of Nile tilapia fingerlings through mechanisms that involve reduction of GHR and IGF-1 expression. |
| Databáze: | OpenAIRE |
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