Exploration of change in persistence patterns of opioid use among patients with non‐cancer and cancer pain over a 3‐year follow‐up period
| Autor: | Munira Izat, Kim Swan Ng, Che Suraya Zin, Hung Ling Tan, Abdul Hadi Mohamed, Lisa Nissen, Asween Rowena Abdullah Sani |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
business.industry Opioid use Cancer Pharmacy Affect (psychology) medicine.disease 030226 pharmacology & pharmacy Persistence (computer science) 03 medical and health sciences 0302 clinical medicine Opioid Medication Persistence Internal medicine Medicine Pharmacology (medical) 030212 general & internal medicine Medical prescription business Cancer pain medicine.drug |
| Zdroj: | Journal of Pharmacy Practice and Research. 50:28-35 |
| ISSN: | 2055-2335 1445-937X |
| DOI: | 10.1002/jppr.1573 |
| Popis: | Background : Little is known about the different patterns of persistent opioid use and whether the patterns of clinical opioid use remain the same throughout long-term opioid therapy. Aim : This study explored the different patterns of persistent opioid use and changes in these patterns over time in patients with non-cancer and cancer pain. Methods : This retrospective cross-sectional study included patients with non-cancer and cancer pain receiving opioid prescriptions during 2013–15 at outpatient tertiary hospital settings in Malaysia. A three-dimensional (3D) persistence measure consisting of treatment intensity, frequency and distribution was used to define persistent opioid users as wide (use opioids most of the days in a year), intermediate (use opioids daily) or strict (use opioids continuously to achieve a therapeutic concentration) users. The number of patients in each persistence group and changes in persistence patterns over time were recorded. Results : Most persistent opioid users in the non-cancer and cancer groups were defined as wide users (9.3% and 4.8%, respectively),followed by intermediate (3.1% and 0.5%, respectively) and strict (1.8% and 0.9%, respectively) users. Over the 3-year study period,a change to a less stringent persistence definition was observed in the non-cancer group, whereas no discernible pattern of change was observed in the cancer group. Conclusion : Changes in the patterns of clinical opioid use over time were detected among persistent opioid users in both the noncancer and cancer groups using a 3D persistence measure. This measure, which is sensitive to changes in the clinical use of opioids over time, could affect future research and practices for better pain management involving opioids. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text