Cognitive changes in patient living with HIV-AIDS and apolipoprotein-E polymorphism: is there an association?

Autor: E. Dellalibera, Paulo Roberto de Brito-Marques, Maria Tereza Cartaxo Muniz, Pedro Augusto Sampaio Rocha-Filho, Carolina da Cunha-Correia
Rok vydání: 2020
Předmět:
Zdroj: Molecular Biology Reports. 47:8757-8762
ISSN: 1573-4978
0301-4851
DOI: 10.1007/s11033-020-05923-4
Popis: Patients with HIV-AIDS treated with antiretroviral drugs still have high prevalence of cognitive disorders and many factors are likely to contribute for ongoing neurologic decline such as chronic low-level infection, coinfections with hepatitis B and C and genetic influences, both the virus and the host. Some evidences suggest that the genetic APOE polymorphism may be an associated risk factor. This study aimed to evaluate the association between APOE polymorphisms and cognitive disorders in patients with HIV-AIDS. This was a cross-sectional study comprising 133 patients aged 19–59 years old, with HIV-AIDS and were assisted at the infectious disease outpatient clinics at Hospital Universitario Oswaldo Cruz, in Recife, Brazil. For cognitive evaluation, Mini-Mental State Examination test (MMSE) and Montreal Cognitive Assessment test (MoCA) were used. The determination of APOE gene polymorphism was performed by using the PCR-RFLP technique. Sociodemographic and clinical characteristics were not significantly associated to APOE e4 polymorphism, except for the high results of CD4 rate (p
Databáze: OpenAIRE
Externí odkaz: