Synthesis and pharmacological activity of a silicon—zinc—boron-containing glycerohydrogel

Autor: N. V. Zil’berberg, L. P. Larionov, O. N. Chupakhin, A. I. Polishchuk, T. G. Khonina, Vasily V. Permikin, M. M. Kokhan, E. Yu. Nikitin, N. P. Evstigneeva, E. V. Shadrina, N. V. Kungurov
Rok vydání: 2019
Předmět:
Zdroj: Russian Chemical Bulletin. 68:1621-1628
ISSN: 1573-9171
1066-5285
DOI: 10.1007/s11172-019-2601-5
Popis: A new pharmacologically active nanostructured silicon—zinc—boron-containing glycerohydrogel was synthesized by the sol—gel method using silicon, zinc, and boron glycerolates as biocompatible precursors. The hydrogel composition and structural features were investigated by transmission electron microscopy, powder X-ray diffraction, IR spectroscopy, atomic emission spectrometry, and elemental analysis; a structural model was proposed. It was found that the 3D framework of the gel is formed by the products of hydrolysis and subsequent (co)condensation of silicon- and boron-containing precursors. Meanwhile, the major part of zinc monoglycerolate does not undergo hydrolytic transformations during gelation, being present in the 3D framework cells as amorphous nano-sized particles. The dispersion medium of the gel is an aqueous glycerol solution of silicon and boron glycerolates, products of their hydrolytic transformations, and water-soluble products of hydrolytic transformations of zinc monoglycerolate. The silicon—zinc—boron gel is nontoxic and possesses wound-healing and antimicrobial activities; it can be considered as a nanostructured dispersed system promising for biomedical applications, which is prepared in a simple and cost-effective way without using catalysts or toxic organic solvents.
Databáze: OpenAIRE
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