Syrian hamsters express diverse MHC class I gene products
| Autor: | D I Watkins, Z W Chen, A L Hughes, A Lagos, A M Lewis, J A Shadduck, N L Letvin |
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| Rok vydání: | 1990 |
| Předmět: | |
| Zdroj: | The Journal of Immunology. 145:3483-3490 |
| ISSN: | 1550-6606 0022-1767 |
| Popis: | MHC class I glycoproteins are highly diverse in most species. The Syrian hamster has long been thought to express monomorphic MHC class I molecules and thus be an exception to this rule. Here we show that Syrian hamsters express diverse MHC class I gene products. The nucleotide sequences of the alpha 1 and alpha-2 domains of classical Syrian hamster MHC class I molecules are highly variable and show evidence of having been under selective pressures at their Ag recognition sites. Interestingly, none of the Syrian hamster class I genes was closely related to their counterparts in the mouse. These observations suggest that Syrian hamsters in the wild may express diverse MHC class I molecules. |
| Databáze: | OpenAIRE |
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