ChemInform Abstract: Synthesis, Characterization and Antimicrobial Activity of Substituted 3-(Phthalazine-1-ylamino)alkanoic Acid Containing Imidoxy Moiety

Autor:	Vijay Kumar Salvi, Ganpat L. Talesara, Archita Bapna, Gangotri Pemawat
Rok vydání:	2010
Předmět:	chemistry.chemical_classification chemistry.chemical_compound Acetic acid chemistry Condensation Moiety Organic chemistry General Medicine Phthalazine Antimicrobial Alkanoic acid Amino acid
Zdroj:	ChemInform. 41
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.201002170
Popis:	Hydrozinolysis of phthalyl derivatives of amino acid 1a-c afforded [(4-oxo-3,4-dihydrophthalazine-1-yl)amino]substituted acetic acid 2a-c, which on reaction with POCl 3 /PCl 5 gave [(4-chlorophthalazine-1-yl)aminolsubstituted acetic acid 3a-c. This when condensed with N-hydroxyphthalimide/N-hydroxysuccinimide 4a-b yielded phthalimido or succinimido-2-({4-phthalazine-1-yl}amino)substituted acetic acid 5a-f. Condensation of compounds 2a-c with ωbromoalkoxyphthalimide 6a-b furnished the corresponding 2-[(3-{2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)oxy]ethyl}-4-oxo-3,4-dihydrophthalazine-1-yl)amino]substituted acetic acid 7a-f. All the compounds were screened for antimicrobial activities.
Databáze:	OpenAIRE
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