Carcinogenesis Marked by Initiation
| Autor: | Vincent L. Wilson |
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| Rok vydání: | 2013 |
| Předmět: | |
| Zdroj: | Disruptive Science and Technology. 1:149-153 |
| ISSN: | 2163-3118 2163-310X |
| Popis: | My last installment in this debate1 focused on the carcinogenesis process as a whole to demonstrate the numerous environmental and physiological factors involved in the multistep processes of carcinogenesis, including the involvement of both somatic mutation and tissue environment dynamics (i.e., Somatic Mutation Theory (SMT) and Tissue Organization Field Theory (TOFT)). In this article, the focus will be primarily in the initiation of carcinogenesis, the all-consuming first step, when the novice cell makes a Faustian bargain2 with the Devil and enters the first of nine circles of Hell.3 Although, there is nothing comedic about the nine prominent changes that have thus far been identified for the development of a malignant tumor.4 The first step is the formation of the initiated cell. By definition, the initiated cell is irreversible due to a newly formed, fixed mutation that is oncogenic. The premise that the origin of the initiated cell occurs by the development of a fixed oncogenic mutation is... |
| Databáze: | OpenAIRE |
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