Synthesis of Aminoalkyl Dibenzofuranone Oxime Derivatives Possessing Anticonvulsant Activity

Autor:	D. M. Ivasheva, S. A. Litvinova, T. A. Voronina, T. A. Gudasheva, A. G. Rebeko, G. V. Mokrov, L. A. Zhmurenko
Rok vydání:	2021
Předmět:	Pharmacology Valproic Acid 010405 organic chemistry Chemistry medicine.medical_treatment Pharmacology toxicology Oxime 01 natural sciences Medicinal chemistry Oxalate 0104 chemical sciences 010404 medicinal & biomolecular chemistry chemistry.chemical_compound Anticonvulsant Active compound Drug Discovery medicine medicine.drug
Zdroj:	Pharmaceutical Chemistry Journal. 54:997-1002
ISSN:	1573-9031 0091-150X
DOI:	10.1007/s11094-021-02309-z
Popis:	A new group of aminoalkyl dibenzofuranone oxime derivatives was designed and synthesized. Several compounds were found to exhibit anticonvulsant activity in the maximum electroshock test. The most active compound was 3,4,6,7,8,9-hexahydrodibenzo[b, d]furan-1(2H)-one O-[2-(diethylamino)ethyl]oxime oxalate (GIZh-347), which at a dose of 60 mg/kg (mice, i.p.) was as effective as valproic acid at a dose of 200 mg/kg.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::9c52dc357af1fa855b222dba4177fa65 https://doi.org/10.1007/s11094-021-02309-z Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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