Vergleichende Untersuchungen zur Ototoxizität des Cisplatin und des Carboplatin
| Autor: | A. Koch, S. Feilen, W. Delb, P. Federspil |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Cisplatin
Chemotherapy Pathology medicine.medical_specialty business.industry medicine.medical_treatment Pharmacology medicine.disease Carboplatin Nephrotoxicity chemistry.chemical_compound Otorhinolaryngology Ototoxicity chemistry Functional methods Total dose Toxicity medicine business medicine.drug |
| Zdroj: | Laryngo-Rhino-Otologie. 72:24-27 |
| ISSN: | 1438-8685 0935-8943 |
| DOI: | 10.1055/s-2007-997847 |
| Popis: | The application of the potent anticancer drug cisplatin is limited by major side effects such as its ototoxicity and its nephrotoxicity. Since carboplatin has been introduced into clinical use, a platinum derivative with less pronounced ototoxicity and nephrotoxicity is available. The aim of this study was to quantify the ototoxicity of carboplatin comparing it to cisplatin using the wellknown guinea-pig model. Using morphological and functional methods it could be shown that the ototoxic damage was by far higher in a group which had received a total dose of 12 kg cisplatin/kg than in a group which had received a dosage of 90 mg carboplat/kg. Our investigations show that the ototoxic potential of cisplatin in the guinea-pig is more than 9 times higher than that of carboplatin. |
| Databáze: | OpenAIRE |
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