High polyunsaturated and monounsaturated fatty acid to saturated fatty acid ratio increases plasma very low density lipoprotein lipids and reduces the hepatic hypertriglyceridemic effect of dietary cholesterol in rats
| Autor: | Chen Ten Wu, Fei Na Chen, Nai Wen Chang, Po-Chao Huang |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
chemistry.chemical_classification
medicine.medical_specialty Very low-density lipoprotein Nutrition and Dietetics Cholesterol Endocrinology Diabetes and Metabolism Phospholipid chemistry.chemical_compound Endocrinology chemistry Internal medicine Low-density lipoprotein Saturated fatty acid medicine lipids (amino acids peptides and proteins) Monounsaturated fatty acid Polyunsaturated fatty acid Lipoprotein |
| Zdroj: | Nutrition Research. 24:73-83 |
| ISSN: | 0271-5317 |
| DOI: | 10.1016/j.nutres.2003.09.002 |
| Popis: | To determine whether high polyunsaturated and monounsaturated fatty acid to saturated fatty acid [(P+M)/S] ratio in diets increases plasma lipoprotein lipids and reduces the hepatic hypertriglyceridemic effect of dietary cholesterol, we compared plasma lipoproteins and liver lipids in 64 rats. Rats were fed diets with the same polyunsaturated fatty acids/saturated fatty acids (P/S) ratio of 1.0, but different (P+M)/S ratios of 1.5, 2, 4, or 5.7 without (experiment 1) or with 1% cholesterol supplement (experiment 2). We found that the plasma total cholesterol (C), and low density lipoprotein (LDL)-C concentrations were significantly higher in rats fed with the (P+M)/S ratio of 5.7 compared with rats fed with the (P+M)/S ratio of 1.5 or 2.0. As to the very low density lipoprotein (VLDL)-C, rats fed with 5.7 or 4.0 ratio had higher concentration than rats fed with 1.5 or 2.0 ratio. With 1% choesterol supplement, when rats were fed with the ratio of (P+M)/S which increased from 1.5, 2, 4 to 5.7, there was a progressive increase in plasma total cholesterol (P=0.0001), total triacylglycerol (TAG, P=0.0091), total phospholipid (PL, P=0.0006), VLDL-C (P=0.0001), VLDL-TAG (P=0.0119), VLDL-PL (P=0.0013), LDL-C (P=0.0001), LDL-TAG (P=0.0006), and LDL-PL (P=0.0001) concentrations. There was also a progressive increase in liver C level (P=0.005) and decrease in liver TAG level (P=0.004) with 1% C supplement. However, without 1% cholesterol supplement, no such a trend was found for plasma total, lipoproteins, and liver lipids. We conclude that high (P+M)/S ratio increases plasma VLDL and LDL lipids and reduces the hepatic hypertriglyceridemic effect of dietary cholesterol in rats. These results suggest that the higher (P+M)/S ratio is more cholesterolemic and hepatocholesterolemic than lower (P+M)/S ratio in rats fed with high-cholesterol diet. |
| Databáze: | OpenAIRE |
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