| Popis: |
A simple and efficient one-pot four-component procedure has been developed for the synthesis of a wide range of compounds containing the (triazolyl)methyl oxo-pyrimidine-carboxylate system from propargyl b-keto esters, various azides, aldehydes, and urea in the presence of catalytic amounts of (AcO)2Cu/sodium ascorbate in AcOH. The method worked well with different aryl and heteroaryl aldehydes, and for a variety of substituents in the triazolyl part of the molecule. The antimicrobial activities of the products were evaluated against two Gram-positive and Gram-negative bacteria, and one fungus. Compound 5j was active against Staphylococcus aureus and Candida albicans. |
