Skin melanoma. State of the problem. Review

Autor:	S. A. Yargunin, A. F. Lazarev
Rok vydání:	2020
Předmět:	0301 basic medicine 03 medical and health sciences medicine.medical_specialty 030104 developmental biology 0302 clinical medicine business.industry 030220 oncology & carcinogenesis medicine General Medicine Skin melanoma business Dermatology
Zdroj:	Russian Journal of Oncology. 24:113-120
ISSN:	2412-9119 1028-9984
DOI:	10.18821/1028-9984-2019-24-3-6-113-120
Popis:	Skin melanoma, being the deadliest form of skin tumor, contributes significantly to cancer mortality and carries a significant and growing public health burden. The incidence of MK is growing steadily throughout the world and is in the nature of a silent epidemic. The critical mortality rate is due to the high metastatic potential of the tumor and the low efficiency of systemic therapy of disseminated forms of the disease. Thanks to a breakthrough in understanding the genetic mechanisms of the appearance of a tumor, the spread and tolerance to treatment, the emergence of a number of targeted and immunological drugs, patients with advanced MK have the hope of prolonging life and even complete cure. However, many diagnostic problems remain; treatment standards; emerging tolerance to therapy. All these questions compel further research into the diagnosis and treatment of this disease.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::9c2b4066e5c2248ccc0dce558eb2cf24 https://doi.org/10.18821/1028-9984-2019-24-3-6-113-120 Zobrazit plný text záznamu