Synthesis of ximelagatran, melagatran, hydroxymelagatran, and ethylmelagatran in H-3 labeled form

Autor:	Charles S. Elmore, Cecilia Ericsson, Roger Simonsson, Gunnar Stenhagen
Rok vydání:	2013
Předmět:	inorganic chemicals Ximelagatran Liver toxicity Chemistry organic chemicals Hydrogen isotope Organic Chemistry Biochemistry Analytical Chemistry Catalysis Drug Discovery medicine Organic chemistry Radiology Nuclear Medicine and imaging Tritium Specific activity Spectroscopy medicine.drug
Zdroj:	Journal of Labelled Compounds and Radiopharmaceuticals. 56:334-337
ISSN:	0362-4803
Popis:	In support of a study designed to better understand the liver toxicity of ximelagatran, ximelagatran, and melagatran, hydroxymelagatran and ethylmelagatran were prepared in tritium labeled form. Incorporation of tritium was achieved by hydrogen isotope exchange using Crabtree's catalyst and later with N-heterocyclic containing Ir catalyst. The tritiated product was then converted into the four target compounds to afford them in high purity and specific activity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::9c295cc95ab8c304704eb4be3ddfc46d https://doi.org/10.1002/jlcr.3028 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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